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Interestingly, the 1.8 kb 5-flanking region of the rat GCLC does not contain any consensus ARE element (5-G/ATG/TAG/CNNNGCA/G-3) (Erickson et al., 2002), but the reporter activity driven by a recombinant rat GCLC-luciferase construct is induced by TBH (Yang et al., 2005a)

Subcutaneous sites include the abdomen and outer upper arms

Most studies on effectiveness have been based on in vitro testing or even conducted under laboratory conditions

But its effects go beyond simple enzyme activation

Acknowledgments The figures in this review were partly illustrated with the assistance of BioRender

Pi Y, Zuo H, Wang Y, et al