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Squire, P., Naude, J., Zentner, A., Bittman, J

Odor identification and discrimination as markers of early Alzheimers disease

Probiotic efficacy is generally measured in colony-forming units (CFU), with typical daily doses ranging from 1 10 9 to 1 10 0 CFU, though clinical benefits are highly dependent on the specific strain or combination of strains, as many effectssuch as the prevention of diarrheal diseasesare strictly strain-specific (28)

In milder or borderline cases, high-dose oral vitamin B12 may be sufficient, depending on absorption and clinical context

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In SOD1 mouse models, endplate denervation was seen prior to clinical weakness and motor neuron loss, suggesting that NMJ compromise occurs early in the pathophysiology of ALS and is often the inciting event prior to lower motor neuron injury (dying back hypothesis) [283]