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Ohashi S, Matsumoto M, Togashi H, Ueno K, Yoshioka M

Although little is known about physiopathological mechanisms underlying APN, a combination of direct toxic effects of ethanol or its metabolites and nutritional deficiencies (mainly thiamine) may offer a plausible explanation to this complication

Ganglion cells responses to NMDA have been observed (Massey and Miller, 1988, 1990, Mittman et al., 1990, Diamond and Copenhagen, 1993, Cohen and Miller, 1994)

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In particular, the problem of under-reporting is difficult to quantify