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This enrolled 390 people with type 2 diabetes, all on insulin, and randomised them to metformin 850 mg three times daily or placebo, with a follow-up of just over 4 years (de Jager et al, 2010)

Mood & Serotonin Regulation : Acts as a vital co-factor in synthesizing neurotransmitters like serotonin and dopamine, helping stabilize mood and ease anxiety

The lesions can develop anywhere, but commonly occur on the legs

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Does GLP-1 Cause Leg Cramps

Bleumink GS, Schut a FC, Sturkenboom MCJM et al (2005) A promoter polymorphism of the insulin-like growth factor-I gene is associated with left ventricular hypertrophy