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When that sebum combines with dead skin cells, environmental debris and certain cosmetics, pores become blocked and bacteria will thrive

This is further supported by the observation that phosphorylation of IB at specific serine residues can be inhibited by dithiocarbamates, pointing to the possibility that NF-B translocation and subsequent activation is mediated by ROS, which might induce a cytosolic kinase activity [54, 55, 103, 104]

That's worth understanding but not worth over-relying on

J Intern Med 248(5):377386

A cruel, vindictive and naughty child taking after his father, despite the best efforts of his kind mother, he becomes a central piece of the story