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In contrast, PINK1-PARKIN independent mitophagy relies on mitophagy receptors, mitochondrial membrane proteins (e.g., BNIP3, BNIP3L/NIX, FKBP8, FUNDC1), which can interact with LC3 or GABARAP proteins to recruit dysfunctional mitochondria to autophagosomes

Ayi, K., Cappadoro, M., Branca, M., Turrini, F

Employing this rat model of HMG-induced lung injury, we observed significant attenuation of the pulmonary injury when experimental animals were complement or neutrophil depleted prior to HMG challenge

These limitations highlight the need for next-generation agents engineered for enhanced CNS delivery, including prodrug strategies, receptor-mediated transcytosis and nanocarrier-based transport systems

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