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Xia WJ, Xu ML, Yu XJ, Du MM, Li XH, Yang T, et al

Petersburg, was independently replicated in 2025 by researchers at Brunel University London

Mechanistically, we found that CRAT downregulation promoted OC growth and metastasis by increasing mitochondrial biogenesis to facilitate mitochondrial metabolism through reducing the acetylation of peroxisome proliferator-activated receptor- coactivator (PGC-1)

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In 2012, the Stockwell team officially named the cancer cell death induced by Erastin and RSL3 as"ferroptosis,"characterized by its iron dependency and lipid peroxidation, contrasting sharply with apoptosis, autophagy, and necrosis [9]