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Adding further complexity, TRIM21 utilizes K48 ubiquitination to degrade VDAC2 in nasopharyngeal carcinoma, suppressing cGAS/STING-mediated immune surveillance [12]

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242 Astragaloside IV inhibits the PI3K/Akt/mTOR pathway by upregulating miR-155 expression, thereby preventing apoptosis and enhancing autophagy to alleviate myelin damage in Schwann cells and improve neurological function in DPN rat models

Western blot analysis further confirmed SACs regulatory effects on the Keap1/Nrf2/GPX4 signaling pathway, showing elevated Nrf2, GPX4, NOQ1, HO1 and xCT protein levels and reduced Keap1 expression in the SAC group compared to the DSS group (Fig

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