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However, oxidative stress happens when the antioxidant defense system of body is overwhelmed by the production of ROS ( Figure 1 )

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Addition of NADPH and GR led to reduction of GRXC2 (Fig

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This link between TNF- and ROS adds another dimension of complexity to the TNF signalling network, as ROS act on numerous proteins required for the regulation of cellular homeostasis, including proteins that mediate cell proliferation, survival, death, differentiation, DNA repair and metabolism 30