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Supplementary Figure 3 Inhibition of AQP4 in astrocytes improve the survival of neurons

ROS generated during oxidative stress can activate the IB kinase (IKK) complex, which phosphorylates IB proteins and marks them for ubiquitin-mediated degradation

A newly discovered class of RNAs that are defined as RNAs of more than 200 base pairs in length, are transcribed from genes but not translated into proteins due to the presence of multiple translational stop codons and, as RNAs, regulate the expression of target genes and proteins to carry out a vast array of biologic functions

Here's how it compares to other commonly used compounds: GHK-Cu Matrixyl (Pal-KTTKS) Epithalon GHK-Cu Matrixyl (Pal-KTTKS) Epithalon GHK-Cu's key differentiator is the depth of its gene expression modulation it doesn't just stimulate one target (like collagen) but appears to reset aging gene expression patterns across thousands of genes

Cardozo G, Mastrogiovanni M, Zeida A et al (2023) Mitochondrial Peroxiredoxin 3 is rapidly oxidized and hyperoxidized by fatty acid hydroperoxides

The plurality of anti-peptide antibodies includes a variety of different antibodies directed against a specific portion of the protein (i.e., against an amino acid sequence containing at least one, preferably only one, epitope)