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Over-loss and muscle pooled SURMOUNT, BMI below 22 reached by about 7% (as early as week 12), toward about 15% by week 88 in the longest trial, clinical underweight under 0.4% (Almandoz 2026)

Common Symptoms of B12-Related Nerve Damage Signs of nerve damage from B12 shortage include numbness, tingling, and pain in hands and feet

The dose you take and how often you take it both play a role in how your body responds

Once prescription authorization is received, the order will be processed and shipped within 24-72 business hours

Timeline expectations : Week 1 Increased energy, reduced appetite

Am J Physiol Heart Circ Physiol 293:H677H683