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Cryo-EM imaging was performed on a Titan Krios at 300 kV accelerating voltage in the Center of Cryo-Electron Microscopy Research Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences (Shanghai, China)

(2020), at the beginning cells were loaded with dye, and after washing and incubation with peptides in glucose-free PBS, the efflux of dye was assessed in the supernatant (Figure 6C)

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All raw data for the electrophysiology studies (corresponding to Figs

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