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371 It was shown that the core promoter regions, contributing to the regulation of ZIP1 expression, are modulated by SP1 as well as CREB

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Yet ncRNA signatures remain heterogeneous across brain regions, patient populations, and experimental models, and only a minority have been validated functionally, highlighting the need for more mechanistic and clinically oriented studies (Table 4)

Furthermore no effort was made either in the EPIC Study trial or in this reported retrospective file review, to determine if any of the dogs actually had enlarged hearts

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