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A 2025 American Journal of Clinical Nutrition study (n=800) noted potassium drops ( 10,000 mcg/week), causing elevated hematocrit (50-55%) due to overactive erythropoiesis

While free GHK-Cu is water-soluble, it struggles to cross the lipid-rich skin barrier

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Local factors comprise pressure, infection, edema, and/or arterial and venous insufficiency

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