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First, the majority of available data are derived from in vitro and animal models, which do not fully capture the complexity, heterogeneity, and long-term progression of human neurodegenerative diseases

Timing of supplementation with the antioxidant N-acetyl-L-cysteine reduces tumor multiplicity in novel, cancer-prone p53 haploinsufficient Tg.AC (v-Ha-ras) transgenic mice but has no impact on malignant progression

Campbell JD, McDonough JE, Zeskind JE, Hackett TL, Pechkovsky DV, Brandsma CA, Suzuki M, Gosselink JV, Liu G, Alekseyev YO, Xiao J, Zhang X, Hayashi S, Cooper JD, Timens W, Postma DS, Knight DA, Lenburg ME, Hogg JC, Spira A

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With significantly increased progression-free survival (PFS) rates and positive radiological responses, Bev was FDA-approved to be used as a second-line treatment or in combination with first-line treatments for recurrent GBM (156, 160, 176, 177)

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