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The apparent permeability (P app A,B ) of M8891 in Caco-2 cells in the absence of cyclosporine A (P-glycoprotein (P-gp) inhibitor) was found to be high (35.7 106 cm/s) and no significant active efflux (ratio: 1.2) was observed

[DOI] [PubMed] [Google Scholar] 47.Trevisani M., Siemens J., Materazzi S., Bautista D.M., Nassini R., Campi B., Imamachi N., Andr E., Patacchini R., Cottrell G.S., et al

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The furthest from replicating human pathophysiology would be other species such as rats, which are not a good model for APAP hepatotoxicity

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Epidemiology and Clinical and Laboratory Findings in Patients