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When kidney function declines, B12 clearance slows, and serum levels can rise

Before being approved for use by health authorities, such as the Medicines and Healthcare products Regulatory Agency (MHRA), all medications, including weight loss injections, must undergo rigorous testing and extensive clinical trials

Most adults can safely get weekly injections indefinitely

These washout periods, which are highlighted in the Summary of Major Modifications and Explanatory Note, are based on the use of these medications according to the maximum manufacturers licensed doses

Beyond Month 6: Maintenance Most patients continue at 2.4 milligrams weekly through month 12, when full clinical trial endpoints are typically reached

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