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In 33 human cancer cell lines, high expression of ketolytic enzymes BDH1 and OXCT1 was associated with KD resistance, as seen in HeLa xenografts where KD accelerated growth

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[42] [43] These properties contribute to the depletion of cysteine from respiratory chain complexes, such as Complexes I and IV, [44] since reactive oxygen species (ROS) produced by the respiratory chain can react with the cysteine residues in these complexes, leading to dysfunctional proteins and potentially contributing to aging