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Comparison of minipig, dog, monkey and human drug metabolism and disposition

Studies (42, 43) have shown that apigenin has a pro-apoptotic effect in human RA-FLS, and it can induce RA-FLS apoptosis by mediating ROS and oxidative stress activator ERK1/2, and mediate apoptotic cell death by activating the apoptotic effector caspase-3/7

The peptide works exclusively through peripheral mechanisms in adipose (fat) tissue rather than through central nervous system pathways that regulate appetite and feeding behavior