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HLE formats half-life extending formats scFc single chain Fc format hetero Fc also designated as hetFc or heterodimeric Fc, hFc HSA human serum albumin Protein instability and in particular protein aggregation, is an increasing challenge in the biotechnology industry, where aggregation is encountered throughout the lifetime of a therapeutic protein, including during refolding, purification, sterilization, shipping, and storage processes

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