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A block size of 4 will be created in six different arrangements (block) to evenly assign patients to experimental groups as follows: Block: LC + ALA, Placebos, LC + ALA, Placebos Block: Placebos, LC + ALA, Placebos, LC + ALA Block: LC + ALA, LC + ALA, Placebos, Placebos Block: Placebos, Placebos, LC + ALA, LC + ALA Block: Placebos, LC + ALA, LC + ALA, Placebos Block: LC + ALA, Placebos, Placebos, LC + ALA Random assignment will be done using computer-generated random numbers prepared by statisticians, and patients will be randomly divided into either the intervention group (LC plus ALA, n = 40) or the control group (placebos, n = 40) by one person, who is not involved in the study

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