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We observed significantly increased deacetylase activity of both SIRT1 and SIRT3 in the liver and spleen of mice treated with Ab68, but not with the non-inhibitory anti-CD38 antibody Ab69 (Fig

Inhibition of NF-b Nuclear Translocation via HO-1 Activation Underlies -tocopheryl Succinate Toxicity

No clear effect of treatment on the short-term neutralizing activity was observed as none of the treatments analyzed (tocilizumab, corticosteroids, type-I IFN or protease inhibitors) were associated with higher or lower magnitude of neutralizing responses