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On the other hand, the in vivo and in vitro models to study this mechanism are diverse, so it is difficult to draw a full picture of the progression of the events toward pancreatic beta-cell dysfunction

10.1016/j.biopha.2022.113317 43 KimH.SeoK

Glutathione works on the skin pigment production by inhibiting tyrosinase, an enzyme involved in making melanin

Immunoblotting Cells were lysed in protein lysis buffer (Cell Signaling) supplemented with Roche complete Protease Inhibitor Cocktail tablets (Sigma-aldrich)

Shaking is forbidden

was supported by funds by the National Heart, Lung, and Blood Institute R01HL146442, R01HL149714, R01HL148151, and R01HL161004, by the National Institute of General Medical Sciences (NIGMS) RM1GM131968 and by the National Institute of Diabetes and Digestive and Kidney diseases (NIDDK) R01DK136945