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230 A similar trial involving 63 women with fibromyalgia found treatment with the antidepressant amitriptyline plus 10 mg of melatonin nightly for six weeks reduced pain more than either amitriptyline or melatonin alone

Symptoms of Muscle Cramps and Spasms The most common sites for muscle cramps are the legs and calf muscles, but they may occur anywhere on the body

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The surefire way of doing that is by injecting into the muscle. 2

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While the total drug exposure remained comparable across all three sites, the thigh produced fewer acute gastrointestinal side effects in the study participants