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When freeze-drying is performed without a protective matrix (such as sucrose or mannitol), residual bound water may cause collapse during the final drying stage

Other contraindications and caution flags include Wilsons disease or another copper-handling disorder, pregnancy, recent surgery, and WADA-tested competition

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However, we stated in the proposed rule that we have received feedback from the MACs regarding pricing information for dental services inextricably linked to covered services, and the MACs have requested information that would support their efforts to assign payment amounts for such dental services