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Potential causes include: Excessive supplementation Liver disease Certain types of leukaemia or cancers Kidney disease High levels require further investigation to rule out underlying medical conditions

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After the comment period closed for the CY 2025 PFS proposed rule, we finalized the proposals without modification in the SAHS billing activity final rule (89 FR 79152, September 27, 2024)

These results led to an improved understanding of WS and identification of a drug combination to help patients, which is currently in an ongoing phase 2 clinical trial (223, 224)