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In POF animal models, induced by drugs, radiotherapy, or heavy metals, resveratrol significantly promotes primordial follicle activation, increases the number of primary, primordial, and growing follicles, stimulates GC proliferation, diminishes ovarian inflammation, maintains ovarian architecture, and rescues oocyte and GC apoptosis (Banu et al., 2016

Evidence has determined that elevated oxidative damage to proteins, lipids, and nucleic acids is a distinctive characteristic of the motor cortex and spinal cord of ALS patients, together with high levels of KEAP1 and a decrease in the NRF2-target genes and related enzymes

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doi: 10.1016/j.nlm.2022.107656 200 VanuytselT.van WanrooyS.VanheelH.VanormelingenC.VerschuerenS.HoubenE.et al

Zesiewicz, Theresa A.|Sullivan, Kelly L.|Maldonado, John L.|Tatum, William O.|Hauser, Robert A

CagriSema is currently in Phase 3 clinical trials