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Possibly, its function of pumping non-metabolized xenobiotics out of the cell and back into the intestinal lumen, may allow more opportunities for phase I activity to metabolize the xenobiotic before it is taken into circulation

[DOI] [PMC free article] [PubMed] [Google Scholar] 43.Drakopoulos P., Van De Vijver A., Schutyser V., Milatovic S., Anckaert E., Schiettecatte J., Blockeel C., Camus M., Tournaye H., Polyzos N.P

All patients were given sublingual lozenges of 1000 mcg cyanocobalamin twice daily for 712 days, after informed consent was obtained

The most important piece of the puzzle

Severe or persistent diarrhea (could indicate C difficile infection)

Preclinical research: gastrointestinal and vascular The original BPC-157 indication, and the only one to have entered formal clinical development, is gastrointestinal