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These benefits, largely mediated by AMPK activation and modulation of HIF-1/PPAR-, PK2/PKRAKT/GSK3, and mTOR/NLRP3 axes, position metformin as a promising therapeutic strategy for preventing and managing DCM

BPC 157: How a Stomach Peptide May Heal Injuries Across the Body by Controlling Blood Vessel Function. Current pharmaceutical design.Study breakdown PubMed 8RPEP-05208Xu, Chuanyang et al

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Additionally, the application of PCs to rat retinal capillary endothelial cells (TR-iBRB2) decreases oxidative stress and inflammasome activation, suggesting involvement of the oxidase/NF-B/NLRP3 axis in mediating their cytoprotective effects (Zou et al., 2023)

MRI, metabolic screening, and genetic testing should be performed as soon as possible in patients with infantile seizures to establish an early diagnosis and prevent neurologic sequelae with timely and effective treatment [79]

"Role of extracellular superoxide dismutase in hypertension"