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Science 363 , eaar3932 (2019)

In CAP patients, the inflammatory response causes the generation of ROS and pro-inflammatory cytokines

Recovery takes longer

Growing older is positively linked to cognitive and biological degeneration such as physical frailty, psychological impairment, and cognitive decline

ALCA, together with alpha-lipoic acid, was shown to improve mitochondrial energy metabolism and decrease oxidative stress leading to improved memory in aged rats [144, 145]

Meanwhile, glutamate oxaloacetate transaminase 1 (GOT1) supports redox homeostasis by maintaining NADPH balance, and glutamate dehydrogenase 2 (GDH2) contributes to mitochondrial signaling that enhances apoptosis resistance [96,102-105]