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Immunoglobulins from patients with Graves disease induce hyaluronan synthesis in their orbital fibroblasts through the self-antigen, insulin-like growth factor-I receptor

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Because NNMT activity intersects methyl donor utilization and nicotinamide handling, experimental inhibition can be used to probe pathway level relationships among methyl economy balance, NAD+ salvage flux, and downstream metabolic signaling in a range of preclinical systems

Its chemical structure was only identified in 1921, by the scientist Frederick Gowland Hopkins