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The 3-hydroxy oxidations are catalyzed by NAD + -dependent hydroxysteroid dehydrogenases of which 3-hydroxysteroid dehydrogenase 2 (HSD3B2) is the most prevalent in gonads and adrenal gland

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If swallowing or overdose is suspected, contact your local poison control center or emergency room immediately

If irritation persists or worsens, discontinue use and consult with your healthcare provider

GSH-induced enhancement of cell viability at 2.5 and 5 M was shown after SM exposure

For example, metformin-loaded nanoparticles attenuate hyperglycemia-associated oxidative stress and promote eNOS phosphorylation in vascular endothelial cells (Mohamed et al., 2024), supporting the feasibility of nanoparticle-based drug delivery strategies