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In this study, we have revealed the importance of the glutamate-generating metabolism, as shown by a complete depletion of glutamine (Gln) in the medium during H

In sickle cell disease (SCD), a genetic blood disorder, the CD8 + T cell three-dimensional genomic structure undergoes rearrangement, causing impaired chromosomal interactions between the anti-ferroptosis gene SLC7A11 and H 2 S biosynthesis-related genes, with downregulated expression making CD8 + T cells more susceptible to ferroptosis, weakening anti-tumor immune function, and promoting tumor growth ( 2 S levels rescues SLC7A11 expression, reduces ferroptosis, and enhances anti-tumor immune responses