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This finding is not surprising, since the NIK-stimulating TNFRs are predominantly expressed on activated T cells and effector T cells [66]

For the free copper ions to be detectable, the intracellular concentration would need to increase by nine orders of magnitude, which would result in approximately one unbound copper atom per cell [13, 15]

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Until properly designed, peer-reviewed human clinical trials are completedand an FDA-regulated production pathway existsclinicians should remain cautious and avoid its clinical use in patients

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