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2009, Nov, 15;25(22):290612 Wang L, Liu Z, Liang R, Wang W, Zhu R, Li J, et al

In that same study, 29% of people taking metformin daily lost greater than or equal to 5% or more of their initial body weight by the end of the first year, compared with 13% of people in the placebo group

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In contrast, the present review adopts a cytokine-centric mechanistic framework, organizing nutraceutical evidence according to their effects on defined inflammatory signaling axes, including NF-B activation, NLRP3 inflammasome signaling, TGF-/SMADmediated fibrogenesis, JAK/STAT pathways, macrophage polarization dynamics, and ferroptosis-associated inflammatory responses across hepatocytes, Kupffer cells, and HSCs

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