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These bioactive metabolites serve dual functions as bioenergetic substrates for neuronal ATP synthesis and as regulators of redox homeostasis and neurogenic pathways

179,180 Red cells contain L-hexonate dehydrogenase, an enzyme that has the capacity to reduce aldoses such as glucose, galactose, or glyceraldehyde to their corresponding polyol (i.e., glucose to sorbitol, galactose to dulcitol, and glyceraldehyde to glycerol)

Lai Q, Liu FM, Rao WL, et al

It is investigational an FDA filing is under review but no regulator has cleared it and these figures are research reference data only, not clinical guidance

On the other hand, mitochondrial dynamic imbalanceparticularly excessive fission-induced mitochondrial fragmentationinterferes with autophagic clearance of damaged mitochondria via mechanisms such as Drp1-Ser616 phosphorylation, identified as a key driver of apoptosis in ischemic myocardial injury

2021 Aug 19;11(1):16869