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Prescription or therapeutic diets for kidney disease are usually fortified with additional B-complex vitamins

Dosage protocols vary depending on the study model and design

The B12-producing bacteria that used to populate our soils have been depleted through modern agricultural techniques, meaning that even grazing livestock is unlikely to get enough B12 for us to absorb efficiently by consuming animal-derived food

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At the most basic level, they're signaling molecules that aren't long enough to be considered proteins

Adjust supplementation based on results rather than guessing