glutathione synthetase deficiency wiki Glutathione Participation in the Prevention

they create what researchers refer to as a massive immunological "energy sink." Because the immune cells (particularly T-cells and memory lymphocytes) are trapped in a state of severe oxidative stress, they are forced to consume excessive amounts of the host's energy just to survive the ongoing cellular damage and attempt repairs

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This means the part of the brain that is responsible for memory, learning, and emotion, loses its function and more beta-amyloid plaques form (Blzquez, Velzquez, Hurtado-Carneiro, & Ruiz-Albusac, 2014)

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Reda A, Veys K, Kadam P, Taranta A, Rega LR, Goffredo BM, Camps C, Besouw M, Cyr D, Albersen M, Spiessens C, de Wever L, Hamer R, Janssen MCH, DHauwers K, Wetzels A, Monnens L, van den Heuvel L, Goossens E, Levtchenko E (2021) Human and animal fertility studies in cystinosis reveal signs of obstructive azoospermia, an altered blood-testis barrier and a subtherapeutic effect of cysteamine in testis