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Wu et al., Multi-responsive nitrobenzene-based amphiphilic random copolymer assemblies

1 It is now widely accepted that the onset and progression of this disease are associated with estrogen dominance and progesterone resistance, 2 a pro-inflammatory pelvic microenvironment, 3 increased neovascularization, 4 apoptosis dysregulation, 5 cell proliferation dysregulation, 6 fibrosis, 7 migration, 8 invasion, 9 dysregulation of oxidative stress and anti-oxidative stress, 10 and alterations in epigenetic factors 11 (Figure 1)

Lefranais et al

Neurochemical Research, 32 , 555567

The two most common MTHFR mutations (polymorphisms) found in humans are: MTHFR C677T (Rs1801133)

These changes are accompanied by increased hippocampal levels of neurotransmitters and neurotrophic factorsincluding 5-HT, GABA, and brain-derived neurotrophic factor (BDNF)along with reduced inflammatory markers such as interleukin-6 (IL-6) (Cai et al., 2022)