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Description

Notch Pathway Activation Targets AML-Initiating Cell Homeostasis and Differentiation

The various phases of lipid peroxidation occurring in a polyunsaturated fatty acid, shown on the right , is described on the left, along the same line

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On the one side, p53 promotes the expression of SAT1 (Qiu et al., 2020), and then increased SAT1 cooperates with ROS to lead to lipid peroxidation (Murphy 2016), further oxidizes PUFAs, and finally causes ferroptosis