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10.1038/ni972 [DOI] [PubMed] [Google Scholar] 97

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Once it enters the cytoplasm, a part of Cu + binds to glutathione (GSH) and is delivered to metallothionein 1/2 (MT1/2) to be restored, and other parts of Cu + are either transferred to the nucleus or ATP7A/7B located in the trans-Golgi network (TGN) by the chaperone antioxidant-1(ATOX1) to facilitate the synthesis of cuproenzymes (Lutsenko et al., 2007) or delivered to superoxide dismutase 1 (SOD1) in the cytoplasm and mitochondrial intermembrane space by a copper chaperone for superoxide dismutase (CCS) to detoxify reactive oxygen species (ROS)

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Translocation of intracellular glutathione to membrane-bound gamma-glutamyl transpeptidase as a discrete step in the gamma-glutamyl cycle: glutathionuria after inhibition of transpeptidase