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While the presented preclinical findings constitute a significant contribution to the search for novel ASD therapies, it is crucial to exercise caution against premature clinical extrapolations that might detract from established evidence-based interventions, including behavioral and educational support [3, 135]

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On the other hand, obeticholic acid, a farnesoid X receptor agonist, can reverse fibrosis, but adverse reactions such as pruritus and dyslipidemia hinder its approval for the treatment of MASH

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MSU crystals preferentially accumulate in regions characterized by slow blood flow, reduced temperature, or repeated mechanical stress, such as the first metatarsophalangeal joint and the auricle (47)

proposed that eicosapentaenoic acid (EPA) may exert a therapeutic effect on depression independently, whereas ALA could potentially increase depression risk (165)