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For example, it is not known whether the complications related to anemia are simply due to a decrease in the number/concentration of circulating RBCs (inducing a systemic dysfunction of normal RBCs) or are rather due to an intrinsic RBC dysfunction ( e.g ., less efficient redox buffering, decreased NO production, increased RBC fragility) or both

Of note, alternative options, such as the combination of gemcitabine and oxaliplatin, may be considered for patients with contraindications to cisplatin 306

[Abstract]2024 Apr 3:2023.06.02.542933

Studies have looked into their effects through clinical trials and detailed analyses

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Gladman D, Nash P, Goto H, Birt J, Lin C-Y, Orbai A-M, et al