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While ROS were also increased by day 2 post-stimulation, restoration of PPP activity and redox homeostasis using galactose by 48 h did not restore antibody production so long as glycolytic flux was suboptimal

Furthermore, ozone therapy role extends to conditions such as bisphosphonate-related jaw osteonecrosis

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The short of it is that fatigue and reduced athletic performance isnt driven so much by muscle glycogen depletion as it is, likely, from a central nervous system mechanism that can be hacked by just giving a tiny bit of carbs during very high intensity exercise to keep the blood supply from dropping the carb equivalent of ~1/2 tsp of honey per 20 min of intense exercise