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D., Huang, B

doi:10.1177/2633494120913032 MedlinePlus

For example, p53 depletion can enhance cell proliferation and survival, disrupt apoptosis and increase genomic instability by altering the expression of REDD1, an mTOR suppressor

More help Evidence Assessment Addressess the biological plausibility, empirical support, and quantitative understanding from each KER in an AOP

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In contrast to their protein-bound counterpart, FAAs can interact with specific receptors present on a wide variety of cells in various parts of the body, including the intestines, where they can activate specific intracellular pathways and confer physiological effects (34, 48)