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86 Also, in an animal model of early Parkinsons disease, long-term KD seemed to be insufficient for the neuroprotective effect

In studies of Hepatocellular Carcinoma (HCC), SUMOylation enhances the ability of NRF2 to scavenge ROS and upregulate PHGDH, promoting de novo serine synthesis

Reducing USP9X lowered the expression of BMAL1 target genes PER2 and CRY1 in mouse neuroblastoma cells, but in U2OS cells, knockdown only slightly reduced rhythm amplitude without changing the period (Zhang et al., 2018)

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Cisplatin Chemistry and Biochemistry of a Leading Anticancer Drug

Consider Other Nutrient Deficiencies Low B12 levels can sometimes be linked to deficiencies in other essential nutrients, such as iron and folate