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J Biol Chem (2014) 289(35):246919

In addition to genetic alterations, Carcinogens present in the environment, such as tobacco smoke, ultraviolet radiation, and certain chemicals, can induce DNA damage and initiate oncogenic processes, and lifestyle factors, such as diet, physical activity, and exposure to toxins, can influence cancer risk by modulating various signaling pathways and epigenetic modifications contribute significantly to cancer development ( Figure 2 )

9 (12), e111220

Anthocyanins, multi-functional natural products of industrial relevance: recent biotechnological advances

In line with this, one other mechanism recently described to be involved in the resistance to GSH depletion is the overexpression of deubiquitinases that inhibit protein degradation following ER-stress (74)