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However, its critical pathogenesis remains unclear

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albicans were co-infected, a thicker, denser biofilm with stronger tolerance to harmful stresses was formed on root canal dentin and glass slides, which can increase bone resorption of osteoclasts, inhibit the bone formation of osteoblasts, upregulate inflammatory cytokines such as IL-6 and TNF-, and ultimately increase the severity of dental pulp diseases

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The hydroxyl groups on the terminal rings can also form mono- or diester derivatives with fatty acids, which are the predominant forms in many natural sources and further contribute to the diversity of astaxanthin compounds observed in biological systems ( Substantial evidence indicates that AST can downregulate microglial activation and reduce the production of cytotoxic factors

It has been described that concentration of vitamin E in the blood was reduced and was associated with ASD-like behaviors in autistic people [57,62]