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Additionally, elevated 3-hydroxybutyrate an important ketone bodyin EP, may indicate enhanced ketogenesis, likely serving as an alternative energy source in the context of increased energy demands or mitochondrial dysfunction 22

Expression and secretion of GAL3 by macrophages is thought to play a role in the activation of renal fibroblasts to its profibrotic prototype 53 , and elevated plasma GAL3 is associated with major adverse kidney events and death 54

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