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Recent developments highlight that these materials provide timely mechanical support (e.g., in situ modulus enhancement to mitigate fibrosis) and enable microenvironment-driven sequential therapies, including targeted delivery of anti-inflammatory/pro-regenerative factors, ROS scavenging, inhibition of enzymatic activity, immune microenvironment remodeling, and precise regulation of cell fate via endogenous stem cell recruitment/differentiation and ferroptosis suppression

10.1146/annurev-animal-022114-110829 146 MizutaniK.IkedaK.KawaiY.YamoriY

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